糖酵解
刺激
再生(生物学)
能量代谢
细胞生物学
新陈代谢
内科学
细胞生长
下调和上调
酶
心脏病学
化学
生物
内分泌学
医学
生物化学
基因
作者
Jing Tan,Ming Yang,Haiping Wang,Conghui Shen,Maoxiong Wu,Xu He,Yandi Wu,Yuanlong Li,Xinghui Li,Tongsheng Huang,Shijie Deng,Zhenyu Yang,Saifei Gao,Hui Li,Jia‐Guo Zhou,Hui Chen,Nan Cao,Weibin Cai
出处
期刊:Cell Reports
[Elsevier]
日期:2022-03-01
卷期号:38 (10): 110468-110468
被引量:11
标识
DOI:10.1016/j.celrep.2022.110468
摘要
As a biological pump, the heart needs to consume a substantial amount of energy to maintain sustained beating. Myocardial energy metabolism was recently reported to be related to the loss of proliferative capacity in cardiomyocytes (CMs). However, the intrinsic relationship between beating rate and proliferation in CMs and whether energy metabolism can regulate this relationship remains unclear. In this study, we find that moderate heart rate reduction (HRR) induces CM proliferation under physiological conditions and promotes cardiac regenerative repair after myocardial injury. Mechanistically, moderate HRR induces G1/S transition and increases the expression of glycolytic enzymes in CMs. Furthermore, moderate HRR induces a metabolic pattern switch, activating glucose metabolism and increasing the relative proportion of ATP production by the glycolytic pathway for biosynthesis of substrates needed for proliferative CMs. These results highlight the potential therapeutic role of HRR in not only acute myocardial protection but also long-term CM restoration.
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