化学
透明质酸
肿瘤缺氧
肿瘤微环境
壳聚糖
缺氧(环境)
右旋糖酐
纳米医学
生物物理学
癌症研究
药理学
生物化学
纳米颗粒
纳米技术
氧气
肿瘤细胞
材料科学
医学
生物
有机化学
放射治疗
内科学
解剖
作者
Wenxue Zhang,Yan Shi,Hu Li,Miao Yu,Jiaxuan Zhao,Hao Chen,Ming Kong
标识
DOI:10.1016/j.carbpol.2022.119418
摘要
The tumor microenvironment (TME) is characterized by low pH, hypoxia, and infiltrated tumor-associated macrophages (TAMs). Therefore, regulation of TAMs polarization into anti-tumor M1 phenotype and meanwhile alleviation of the hypoxia in TME are expected to improve anti-tumor therapeutic efficacy. To this end, a novel in situ injectable nano-complexed hydrogel was developed in this study for combining tumor therapy. Thereunto, hyaluronic acid modified transfersomes loaded with chlorogenic acid functioned to reverse M2 type into M1 type via CD44 mediated internalization, the nanomedicine was entrapped in Schiff-based crosslinked injectable hydrogel (fabricated with carboxymethyl chitosan and oxidized dextran) whose linkage was labile to the acidic TME for controlled drug release. Moreover, catalase was integrated in the hydrogel enabling to convert hydrogen peroxide in TME into dissolved oxygen and alleviate tumor hypoxia. The multifunctional nano-complexed injectable hydrogel was verified to efficiently inhibit tumor growth through synergetic effects of hypoxia alleviation and TAMs polarity regulation.
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