A Review on Synthetic Approaches of Phenanthridine

Abstract: The phenanthridine family is widely found in medicinal chemistry and material science because of the biological activity and its presence in a variety of significant natural products and synthetic dye stuffs. The phenanthridine has many clinical applications, for e.g., being used as an anticancer agent, possessing antibacterial, antiprotozoal, pharmaceutical, and optoelectronic properties. Many methods have been reported for the synthesis of phenanthridine and phenanthridine alkaloids, such as Pd catalyzed C-C bond formation, a reaction involving C-H activation, radical, microwave-assisted, transition metal-catalyzed, one-pot cascade, benzyne mediated, photochemical, hypervalent iodine promoted methods, etc. Here, we have summarized the literature data from 2014 to the present concerning novel or improved synthetic approaches.