医学
炎症性肠病
疾病
炎症性肠病
流行病学
克罗恩病
衰老
重症监护医学
人口老龄化
梅德林
人口
老年学
免疫学
病理
内科学
环境卫生
生物
生物化学
作者
Adam S. Faye,Jean Fréd́eric Colombel
出处
期刊:Inflammatory Bowel Diseases
[Oxford University Press]
日期:2021-04-27
卷期号:28 (1): 126-132
被引量:37
摘要
Evidence from recent epidemiological data suggests that the patient population with inflammatory bowel disease (IBD) is chronologically aging. As these individuals become older, cellular senescence leads to a state of chronic inflammation. This process, known as inflammaging, is thought to be closely linked with biological aging and may be upregulated within IBD. As a consequence, we see an increased risk of aging-related disorders within IBD. In addition, we see that frailty, which results from physiologic decline, is increasing in prevalence and is associated with adverse clinical outcomes in IBD. As such, in this review we explore the potential overlapping biology of IBD and aging, discuss the risk of aging-related disorders in IBD, and describe frailty and its relation to clinical outcomes within IBD. Finally, we discuss current considerations for clinical care and potential research avenues for further investigation.
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