Failures of Valve-sparing Aortic Root Replacement Using the Root Remodeling Technique

Abstract Background Valve failure may occur after valve-sparing aortic root replacement. Little is known about the exact mechanisms of failure. We analyzed our experience with reoperations after aortic root remodeling to determine failure modes, operative risk, and long-term outcome. Methods Between 11/1995 and 12/2019, 1084 patients were treated by root remodeling. Of these, 54 (49 male, 8 to 79 years) underwent reoperation for valve failure (1 week to 16 years postoperatively). The indications for reoperation were aortic regurgitation (n=39), aortic stenosis (n=6), endocarditis (n=7), or ventricular septal defect (n=2). The main causes of valve failure were cusp repair failure (n=29), endocarditis (n=7), and cusp retraction (n=8). The patients were treated by valve replacement (n=40) or cusp repair (n=14). In 6 individuals, combined replacement of valve and root was performed. All 54 patients were followed (mean 69±54 months after reoperation), 1 patient was lost to follow-up. Results No patient died in hospital or developed atrioventricular block; twelve patients died late with 10- and 15-year survival of 87%±5.1% and 64%±10.6%. Of the 14 patients who underwent repeat cusp repair, 7 (50%) are still alive with stable valve function, 17 months to 15 years after their reoperation. Eleven patients required a second reoperation leading to a freedom from repeat reintervention of 68%±9.7% at 15 years. Conclusions The main causes of failure of root remodeling are cusp related. Reoperations can be performed with low morbidity and mortality. In selected patients, isolated cusp repair may be an option.