痴呆
血压
调解
认知
内科学
脉冲压力
认知障碍
医学
阿尔茨海默病
舒张期
疾病
脑脊液
认知功能衰退
心理学
心脏病学
肿瘤科
精神科
法学
政治学
作者
Hao Hu,Meng Li,Yanlin Bi,Wei Zhang,Wei Xu,Xue‐Ning Shen,Ya‐Nan Ou,Ya‐Hui Ma,Qiang Dong,Lan Tan,Jin‐Tai Yu
摘要
This study delineated the interrelationships among blood pressure (BP), cerebrospinal fluid (CSF) core biomarkers of Alzheimer's disease (AD), and cognition.The linear regression analyses were conducted in 1546 non-demented participants (mean age of 61.58 years, range 40 to 89 years; 40% female; average days of BP measurement, 9.10 days). Mediation analyses with 10,000 bootstrapped iterations were used to explore the mediation effects.A clear age-related pattern of BP was delineated. Mid-life hypertension (especially systolic BP), late-life lower diastolic BP, as well as mid- and late-life higher pulse pressure were associated with cognitive impairment and tau-related biomarkers. BP variability was associated only with cognition but not with CSF biomarkers. Overall, the associations between BP and cognition were partially mediated (proportion: 11% to 30%) by tau pathologies, independently of amyloid pathology.Tau pathologies might play important roles in the relationship between BP and cognition, with significant age- and BP-type dependences.
科研通智能强力驱动
Strongly Powered by AbleSci AI