Photobiomodulation induces murine macrophages polarization toward M2 phenotype

Photobiomodulation using light-emitting diode (LED) treatment has analgesic and anti-inflammatory effects which can be an effective therapeutic associated with serum therapy for local treatment of snakebites. Here we explored the effects of LED treatment on isolated macrophage under Bothrops jararacussu venom. Results showed that LED induced IL-6 and TNF-α genes down-regulation and, TGF and ARG1 genes up-regulation which indicates a polarization of macrophages to an M2 phenotype contributing to both tissue repair and resolution of inflammation. • Light Emitting Diode treatment induced the macrophage polarization toward a M2 phenotype under B. jararacussu venom action. • Light Emitting Diode treatment did not interfere with phagocytosis by macrophages under B. jararacussu venom action. • Light Emitting Diode treatment did not impede with macrophages lipid droplets formation under B. jararacussu venom action.