p38丝裂原活化蛋白激酶
生物
细胞凋亡
病毒复制
炎症
MAPK/ERK通路
抑制性突触后电位
药理学
病毒学
免疫学
细胞生物学
信号转导
病毒
神经科学
遗传学
作者
Zhe Zhang,Busen Wang,Shipo Wu,Yanbo Wen,Xinyi Wang,Xiaohong Song,Jinlong Zhang,Lihua Hou,Wei Chen
出处
期刊:Virology
[Elsevier]
日期:2017-08-01
卷期号:508: 150-158
被引量:15
标识
DOI:10.1016/j.virol.2017.05.012
摘要
Enterovirus71 (EV71) is the major causative agent of hand, foot and mouth disease, which threatens the health of infants and young children. The expression of inflammatory cytokines induced by this viral infection aggravate the illness. Here, we describe the anti-EV71 activity of a specific p38 inhibitor that regulates the p38-MAPK signaling pathway. PD169316 was specifically selected from a MAPK compound library due to its significant inhibitory effect on EV71 replication. PD169316 also reduced EV71-induced apoptosis. Animal experiments showed that PD169316 can dampen the replication of EV71, reduce tissue damage and inhibit the release of inflammatory cytokines, thereby alleviating the severe diseases caused by EV71 in suckling mice.
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