药物发现
背景(考古学)
化学
多样性(控制论)
纳米技术
计算生物学
组合化学
生化工程
计算机科学
生物
工程类
生物化学
材料科学
人工智能
古生物学
出处
期刊:The Royal Society of Chemistry eBooks
[The Royal Society of Chemistry]
日期:2014-10-03
被引量:16
标识
DOI:10.1039/9781782623113
摘要
This book reviews macrocycles in drug discovery, both those of natural origin and semi-synthetic derivatives of natural products, and those designed and synthesized based on principles of medicinal chemistry. The medicinal chemistry of macrocyclic natural products is interesting in itself, but lessons learned from these compounds, in terms of the relationship between structure and desirable physicochemical properties, are now informing the design of fully synthetic macrocyclic drug candidates against a variety of targets including kinases, ATPases, proteases, GPCRs and others. Furthermore, as more non-classical drug targets, such as protein–protein interactions, are pursued in the pharmaceutical industry, macrocyclic molecules are generating increasing interest as they offer a way to provide drug–protein interactions that cover a larger surface area than traditional small molecules. A variety of macrocycles have become important drugs or have been identified as leads to marketed drugs. This text will discuss these compounds, their pharmacology and synthesis, in the context of their broad chemotype as compounds composed of large rings. Providing a wide reaching review of this important area in a single volume, this book will be of interest to biochemists, pharmaceutical scientists and medicinal chemists working in industry or academia.
科研通智能强力驱动
Strongly Powered by AbleSci AI