免疫学
医学
免疫系统
过敏
免疫疗法
过敏原
免疫耐受
敏化
免疫球蛋白E
食物过敏
免疫
抗体
作者
Wei Li,Zhuo Zhang,Rong Tian,Ke Zhang
标识
DOI:10.2174/13816128113199990051
摘要
Subcutaneous allergen specific immunotherapy is an effective treatment of IgE-mediated allergies, but it requires repeated allergen injections with a risk of systemic allergic reactions. Other routes of immunization had been explored to improve patient compliance and safety. Skin is not only a physical barrier between the body and outside world, but also an important immune organ eliciting innate and adaptive immune function. Skin has been used as an ideal site for vaccination of infectious diseases. Food allergen topically applied onto disrupted skin can induce sensitization and food allergy would develop subsequently. However, immune tolerance would be induced if the skin barrier is kept intact. Several mice and human studies on epicutaneous immunotherapy showed successful treatment on IgE-induced allergy models or allergic diseases. Migratory Langerhans cells might play a decisive role in the induction of different immune responses. Further research on the underlying mechanism of the crosstalk between skin and gut or airway is helpful for the understanding of many protective or sensitizing immune responses induced via skin, and also is helpful for the development of new strategy for the treatment of allergic disease. Keywords: Skin, food allergy, immunization, tolerance, immunotherapy, epicutaneous, Langerhans cells, peanut.
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