Effect of Saw Palmetto Soft Gel Capsule on Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia: A Randomized Trial in Shanghai, China

No AccessJournal of UrologyAdult urology1 Feb 2008Effect of Saw Palmetto Soft Gel Capsule on Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia: A Randomized Trial in Shanghai, Chinais accompanied byMechanisms by Which a Phytotherapeutic Drug Influences Bladder Activity in Rats Rong Shi, Qiungwen Xie, X. Gang, Jing Lun, Life Cheng, Allan Pantuck, and Jianyu Rao Rong ShiRong Shi School of Public Health, Shanghai, People's Republic of China , Qiungwen XieQiungwen Xie School of Public Health, Shanghai, People's Republic of China , X. GangX. Gang School of Public Health, Shanghai, People's Republic of China , Jing LunJing Lun Ren Ji Hospital, Shanghai, People's Republic of China , Life ChengLife Cheng Shanghai Jiao Tong University and Za Pu Community Health Service Center of Shanghai, Shanghai, People's Republic of China , Allan PantuckAllan Pantuck Department of Urology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California , and Jianyu RaoJianyu Rao Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California View All Author Informationhttps://doi.org/10.1016/j.juro.2007.09.032AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We determined the effect of Prostataplex™ in men with lower urinary tract symptoms associated with benign prostatic hyperplasia. Materials and Methods: A total of 92 Chinese men between 49 and 75 years old with lower urinary tract symptoms were randomly assigned in this double-blind, placebo controlled trial. The 46 patients in the intervention group were given 2 Prostataplex soft gels daily for 12 weeks, while the 46 in the control group were given 2 placebo soft gels for the same time. Results: The treated and control groups appeared to have more than a 95% compliance rate, as judged by counting the remaining pills in the bottle collected at the end of trial months 1 to 3. After 12 weeks of intervention the mean ± SD maximum urinary flow rate was significantly higher in the treatment group than in the control group (14.07 ± 2.56 vs 11.74 ± 1.23 ml per second, p <0.001), while relative urinary resistance was significantly lower in the treatment group than in the control group (2.35 ± 0.83 vs 3.02 ± 1.18, p = 0.002). While there was no significant difference in mean prostate volume or International Prostate Symptom Score between the 2 groups, 18 of 46 patients (39.1%) in the treatment group showed an International Prostate Symptom Score improvement (decrease of 3 or greater) after intervention, whereas only 1 of 46 (2.2%) in the control group showed an International Prostate Symptom Score improvement (chi-square test p <0.001). Conclusions: Prostataplex may have short-term effects in improving symptoms and objective measures in Chinese men with lower urinary tract symptoms associated with benign prostatic hyperplasia. References 1 : The ageing male. World J Urol2002; 20: 4. Google Scholar 2 : Proscar Long-term Efficacy and Safety Study: Storage (irritative) and voiding (obstructive) symptoms as predictors of benign prostatic hyperplasia progression and related outcomes. PLESS Study Group. Eur Urol2002; 42: 1. 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Google Scholar © 2008 by American Urological AssociationFiguresReferencesRelatedDetailsCited byMcVary K, Roehrborn C, Avins A, Barry M, Bruskewitz R, Donnell R, Foster H, Gonzalez C, Kaplan S, Penson D, Ulchaker J and Wei J (2011) Update on AUA Guideline on the Management of Benign Prostatic HyperplasiaJournal of Urology, VOL. 185, NO. 5, (1793-1803), Online publication date: 1-May-2011.Related articlesJournal of Urology14 Dec 2007Mechanisms by Which a Phytotherapeutic Drug Influences Bladder Activity in Rats Volume 179Issue 2February 2008Page: 610-615 Advertisement Copyright & Permissions© 2008 by American Urological AssociationKeywordsurination disordersprostateSerenoaprostatic hyperplasiaMetrics Author Information Rong Shi School of Public Health, Shanghai, People's Republic of China More articles by this author Qiungwen Xie School of Public Health, Shanghai, People's Republic of China More articles by this author X. Gang School of Public Health, Shanghai, People's Republic of China More articles by this author Jing Lun Ren Ji Hospital, Shanghai, People's Republic of China More articles by this author Life Cheng Shanghai Jiao Tong University and Za Pu Community Health Service Center of Shanghai, Shanghai, People's Republic of China More articles by this author Allan Pantuck Department of Urology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California More articles by this author Jianyu Rao Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California More articles by this author Expand All Advertisement PDF downloadLoading ...