脱氢表雄酮
类固醇
化学
药理学
肝细胞癌
癌症研究
细胞培养
组合化学
作者
Shaoyong Ke,Yanhong Wei,Liqiao Shi,Qingyu Yang,Ziwen Yang
出处
期刊:Anti-cancer Agents in Medicinal Chemistry
[Bentham Science]
日期:2013-09-30
卷期号:13 (8): 1291-1298
被引量:19
标识
DOI:10.2174/18715206113139990323
摘要
A series of dehydroepiandrosterone derivatives containing dihydrazone unit was synthesized via a convenient condensation
procedure, and which were evaluated for their potential anticancer activities. The preliminary assays indicated that some of the newly
synthesized compounds exhibited good antitumor activities against human hepatocellular liver carcinoma (HepG2), heptoma (Huh-7),
gastric cancer (BGC-823) and breast adenocarcinoma (MCF-7) cell lines compared with 5-fluorouracil (5-FU), which might be
considered as promising lead scaffold for further design and synthesis of potential anticancer agents.
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