Preparation and stability of iodine/α-cyclodextrin inclusion complex

Inclusion complexes of iodine and α-cyclodextrin were prepared using the coprecipitation method. The complexes obtained were characterized in their solid state using differential scanning calorimetry and in their liquid phase using spectrophotometry, titrimetry and electrochemistry assays. The inclusion and preparation yields were determined. The 1:1 stoichiometry ratio of the inclusion compound was estimated on the basis of the inclusion yield. After optimization of the parameters of the laboratory assays, a scale-up experiment for the complex preparation was carried out. Stability studies showed that, after 16 months preservation, the inclusion complex remained quite stable and suitable for industrial scale-up according to a number of conditions.