微核试验
细胞松弛素B
微核
姐妹染色单体
剂量学
胞质分裂
遗传学
染色体畸变
生物
细胞松弛素
染色体
物理
光学
分子生物学
化学
核医学
医学
细胞分裂
细胞
基因
毒性
有机化学
细胞骨架
作者
J. Prosser,Jayne Moquet,David Lloyd,Alan Edwards
标识
DOI:10.1016/0027-5107(88)90228-x
摘要
An examination of the cytokinesis-blocked micronucleus technique confirmed its potential usefulness as a method of biological dosimetry for radiation accidents. Several advantages of the system are discussed. It has been demonstrated that under the conditions of these experiments, the blocking agent, cytochalasin B does not induce micronuclei or unstable chromosome aberrations. The induction of sister-chromatid exchanges proved just significant. Analysis of the dose response for 250 kVp X-rays indicates that although the Y = αD + βD2 model fits the data, the relationship does not correspond to that for total aberration induction as might have been expected. The background frequency of micronuclei and the value of the α coefficient are higher than for total aberrations and the β term is lower. This indicates that simple incorporation of acentric chromosome fragments into micronuclei may not wholly account for the phenomenon.
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