生物
CD28
细胞生物学
下调和上调
肿瘤坏死因子α
激活剂(遗传学)
抗原
转录因子
分子生物学
效应器
胚胎干细胞
受体
基因
免疫系统
T细胞
免疫学
遗传学
作者
Michelle M Swallow,Jeffrey J. Wallin,William C. Sha
出处
期刊:Immunity
[Elsevier]
日期:1999-10-01
卷期号:11 (4): 423-432
被引量:426
标识
DOI:10.1016/s1074-7613(00)80117-x
摘要
In a screen to identify genes induced by NF-kappaB/Rel transcription factors, we cloned a novel gene, b7h, that is a close homolog of B7 costimulatory ligands expressed on antigen-presenting cells. B7h can costimulate proliferation of purified T cells through a receptor on T cells distinct from CD28 or CTLA-4. Surprisingly, although B7h is expressed in unstimulated B cells, its expression is induced in both 3T3 cells and embryonic fibroblasts treated with TNFalpha, and it is upregulated in nonlymphoid tissues of mice treated with LPS, a potent activator of TNFalpha. These data define a novel costimulatory ligand for T cells and suggest that induction of B7h by TNFalpha may function as a mechanism to directly augment recognition of self during inflammation.
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