孕烷
代谢物
睾酮(贴片)
化学
雄甾烷
新陈代谢
阿尔法(金融)
立体化学
类固醇
光谱分析
色谱法
生物化学
生物
内分泌学
激素
医学
光谱学
物理
护理部
患者满意度
量子力学
结构效度
作者
Shashi B. Mahato,Sukdeb Banerjee,Niranjan P. Sahu
出处
期刊:Steroids
[Elsevier]
日期:1984-05-01
卷期号:43 (5): 545-558
被引量:23
标识
DOI:10.1016/s0039-128x(84)90180-6
摘要
Microbial transformations by a Bacillus sp. were employed as a means of preparing potentially important derivatives of progesterone and testosterone. Each microbial metabolite was subjected to structure elucidation employing 1H and 13C nmr, mass spectral and cd analysis. Hplc was used for the determination of the percentages of the metabolites formed. The progesterone metabolites were characterised as 14-hydroxy-4-pregnene-3,20-dione (II), 14-hydroxy-5 alpha -pregnane-3,6,20-trione (III), 11 alpha-hydroxy-5 alpha-pregnane-3, 6,20-trione (IV) and 11 alpha,14-dihydroxy-4-pregnene-3,20-dione (V). The testosterone analogs were identified as 4-androstene-3,17-dione (VII), 17 beta-hydroxy-5 alpha-androstane-3,6-dione (VIII), 14-hydroxy-4-androstene-3,17-dione (IX) and 14, 17 beta-dihydroxy-4-androsten-3-one (X). The availability of the metabolites enabled complete elucidation of their 13C nmr spectra.
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