表位
抗原
化学
计算生物学
氨基酸残基
生物
生物化学
肽序列
免疫学
基因
作者
A. S. Kolaskar,Prasad Tongaonkar
出处
期刊:FEBS Letters
[Wiley]
日期:1990-12-10
卷期号:276 (1-2): 172-174
被引量:1173
标识
DOI:10.1016/0014-5793(90)80535-q
摘要
Analysis of data from experimentally determined antigenic sites on proteins has revealed that the hydrophobic residues Cys , Leu and Val , if they occur on the surface of a protein, are more likely to be a part of antigenic sites. A semi‐empirical method which makes use of physicochemical properties of amino acid residues and their frequencies of occurrence in experimentally known segmental epitopes was developed to predict antigenic determinants on proteins. Application of this method to a large number of proteins has shown that our method can predict antigenic determinants with about 75% accuracy which is better than most of the known methods. This method is based on a single parameter and thus very simple to use.
科研通智能强力驱动
Strongly Powered by AbleSci AI