自身免疫
肝细胞生长因子
免疫学
炎症
细胞因子
免疫系统
调节性T细胞
效应器
自身免疫性疾病
医学
生物
T细胞
抗体
白细胞介素2受体
内科学
受体
作者
Nicolas Molnarfi,Mahdia Benkhoucha,Hiroshi Funakoshi,Toshikazu Nakamura,Patrice H. Lalive
标识
DOI:10.1016/j.autrev.2014.11.013
摘要
Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases. HGF was reported to prevent and attenuate disease progression by influencing multiple pathophysiological processes involved in inflammatory and immune response, including cell migration, maturation, cytokine production, antigen presentation, and T cell effector function. In this review, we discuss the actions and mechanisms of HGF in inflammation and immunity and the therapeutic potential of this factor for the treatment of inflammatory and autoimmune diseases.
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