两亲性
透射电子显微镜
超分子化学
氯丙嗪
药物输送
动态光散射
药品
胶束
透射率
材料科学
化学
抗精神病药
结晶学
纳米技术
化学工程
有机化学
共聚物
抗精神病药
纳米颗粒
药理学
光电子学
晶体结构
程序设计语言
聚合物
精神分裂症(面向对象编程)
计算机科学
水溶液
工程类
医学
作者
Zhanbin Qin,Dong‐Sheng Guo,Xiaoning Gao,Yu Liu
出处
期刊:Soft Matter
[The Royal Society of Chemistry]
日期:2013-12-11
卷期号:10 (13): 2253-2263
被引量:65
摘要
We report here a supramolecular strategy to directly assemble the small molecular antipsychotic drug chlorpromazine (CPZ) into nanostructures, induced by p-sulfonatocalix[4]arene (SC4A) and p-sulfonatocalix[4]arene tetraheptyl ether (SC4AH), with high drug loading efficiencies of 61% and 46%, respectively. The binary host-guest assembly process was monitored using optical transmittance measurements, and the size and morphology of these two kinds of supra-amphiphilic assemblies were identified using a combination of light scattering and high-resolution transmission electron microscopy, which showed solid spherical micelles. This strategy presents new opportunities for the development of high loading drug-containing carriers with easy processability for drug delivery.
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