Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease

Journal Article Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease Get access Stefka B. Petkova, Stefka B. Petkova 1Jackson Laboratory, Bar Harbor, ME 04609, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Shreeram Akilesh, Shreeram Akilesh 1Jackson Laboratory, Bar Harbor, ME 04609, USA4Present address: Department of Pathology, Washington University, St Louis, MO, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Thomas J. Sproule, Thomas J. Sproule 1Jackson Laboratory, Bar Harbor, ME 04609, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Gregory J. Christianson, Gregory J. Christianson 1Jackson Laboratory, Bar Harbor, ME 04609, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Hana Al Khabbaz, Hana Al Khabbaz 1Jackson Laboratory, Bar Harbor, ME 04609, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Aaron C. Brown, Aaron C. Brown 1Jackson Laboratory, Bar Harbor, ME 04609, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Leonard G. Presta, Leonard G. Presta 2Department of Antibody Engineering, Genentech Inc., South San Francisco, CA, USA5Present address: Schering-Plough Biopharma, Palo Alto, CA, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Y. Gloria Meng, Y. Gloria Meng 3Department of Assay and Automation Technology, Genentech Inc., South San Francisco, CA, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Derry C. Roopenian Derry C. Roopenian 1Jackson Laboratory, Bar Harbor, ME 04609, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar International Immunology, Volume 18, Issue 12, December 2006, Pages 1759–1769, https://doi.org/10.1093/intimm/dxl110 Published: 31 October 2006 Article history Received: 25 April 2006 Accepted: 20 September 2006 Published: 31 October 2006