Vascular Endothelial Growth Factor-driven Glioma Growth and Vascularization in an Orthotopic Rat Model Monitored by Magnetic Resonance Imaging

Our model elucidates glioma growth and vascularization as strongly VEGF dependent, which is consistent with human gliomas. Thus, this model is suitable for testing antiangiogenic strategies to interfere with the VEGF/VEGF receptor system, as well as for exploring VEGF-independent mechanisms using the antisense-transfected clone.