光敏剂
光动力疗法
材料科学
纳米医学
磁共振成像
纳米颗粒
共轭体系
荧光寿命成像显微镜
体内
磁性纳米粒子
临床前影像学
纳米技术
药物输送
氯
荧光
化学
光化学
医学
光学
聚合物
有机化学
放射科
物理
生物技术
复合材料
生物
作者
Peng Huang,Zhiming Li,Jing Lin,Da‐Peng Yang,Guo Gao,Cheng Xu,Le Bao,Chunlei Zhang,Kan Wang,Hua Shi,Hengyao Hu,Daxiang Cui
出处
期刊:Biomaterials
[Elsevier]
日期:2011-05-01
卷期号:32 (13): 3447-3458
被引量:240
标识
DOI:10.1016/j.biomaterials.2011.01.032
摘要
A major challenge in nanotechnology and nanomedicine is to integrate tumor targeting, imaging, and selective therapy functions into a small single nanoparticle (<50 nm). Herein, photosensitizer-conjugated magnetic nanoparticles with ∼20 nm in diameter were strategically designed and prepared for gastric cancer imaging and therapy. The second generation photosensitizer chlorin e6 (Ce6) was covalently anchored on the surface of magnetic nanoparticles with silane coupling agent. We found that the covalently incorporated Ce6 molecules retained their spectroscopic and functional properties for near-infrared (NIR) fluorescence imaging and photodynamic therapy (PDT), and the core magnetic nanoparticles offered the functions of magnetically guided drug delivery and magnetic resonance imaging (MRI). The as-prepared single particle platform is suitable for simultaneous targeting PDT and in vivo dual-mode NIR fluorescence imaging and MRI of nude mice loaded with gastric cancer or other tumors.
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