Comparison of several commonly used detection indicators of cell senescence

Cell senescence is the state of irreversible growth arrest that can be triggered by a variety of different cellular stresses. Currently, the commonly used detection indicators involved in the study of cell senescence include senescence-associated β-galactosidase, Clusterin, Telomeres/Telomerase, senescence-associated heterochromatin foci, senescence-associated secretory phenotype, senescence marker protein-30, tumor suppressor genes p53 and p16, and other indicators such as Ki67 and decoy receptor 2. These indicators are widely used in the study of cell senescence, each with its own characteristics, advantages, and disadvantages. This review summarizes several commonly used cell senescence indicators and compares their accuracy, credibility, specificity, and the scope of their potential application.