脂质体
脂类学
鞘磷脂
血管性痴呆
痴呆
磷脂酰胆碱
胆固醇
内科学
神经酰胺
发病机制
医学
生物
内分泌学
生物化学
疾病
磷脂
细胞凋亡
膜
作者
Yue Liu,Nady Braidy,Perminder S. Sachdev
标识
DOI:10.1016/j.jalz.2018.06.1619
摘要
At present, the molecular basis of vascular dementia (VaD) remains elusive. Comparative lipidomic analyses of VaD and ‘healthy’ age-matched controls may provide new insights to the possible vascular mechanisms in the pathogenesis of dementia. Plasma samples were collected from Bankstown-Lidcombe hospital with VaD patients (n=50) and normal controls (n=50). Lipids were extracted and liquid chromatography coupled to mass spectrometry was used to comprehensively analyze the plasma lipidome in VaD and normal controls. The abundance of lysophospholipids and sphingomyelin were significantly higher in VaD than in normal controls. Ceramides(Cer), cholesterol(CHE), phopholipids, glycerolipids for VaD were significantly lower in VaD than for normal controls. Phosphatidylcholine(PC) was not significantly different between the 2 groups, but the abundance of subgroup PC32, PC33, PC35, PC36, PC39, PC40, PC42 were significantly higher in VaD than in control, and other subgroups showed opposite results. Lipidomics can help to predict development of VaD.
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