Insights from Brazilian supercentenarians

Supercentenarians provide a rare human model of exceptional longevity, marked by unique immune, genetic, and metabolic profiles that support resilience against age-related decline. Brazil's highly admixed population offers unparalleled opportunities to uncover protective mechanisms often missed in more homogeneous cohorts. Here, we describe ongoing genomic and cellular studies of a nationwide Brazilian cohort, featuring individuals who remained highly functional and survived COVID-19 unvaccinated. These individuals allow us to investigate molecular, immunological, and systemic pathways of resilience, offering insights that may inform strategies to extend health span.