Ultrasound-Triggered Type I Supramolecular Photosensitizer for Precise In Situ Chemiluminescence-Based Photodynamic Cyclic Therapy

can be converted into •OH via CRET-mediated PDT cycle, which is the most reactive and toxic ROS in biology. Additionally, the US-induced cavitation effect enhances CL intensity, thereby achieving US-triggered and intramolecular CRET codriven in situ cyclic CL-PDT. To enhance the targeting efficiency of RDL, we construct biomimetic targeting nanoparticles, RDL@RM NPs, by coating with hybrid cell membrane shells. The RDL@RM NPs enable precise targeting of inflammation sites, thereby effectively eradicating pathogens in deep hypoxic tissues via CL-PDT. This research lays the groundwork for the development of US-triggered supramolecular CL-based PSs and their application in treating deep-seated bacterial infections.