巨噬细胞极化
氧化应激
溃疡性结肠炎
下调和上调
炎症
信号转导
药理学
炎症性肠病
促炎细胞因子
医学
结肠炎
一氧化氮
细胞凋亡
癌症研究
化学
免疫学
一氧化氮合酶
巨噬细胞
肿瘤坏死因子α
PI3K/AKT/mTOR通路
体内
活性氧
细胞因子
流式细胞术
汤剂
作者
Shengwei Li,Guanghui Yuan,Chan Chen,Jihong Li Yuxiong Lu,Xing Zhang
摘要
In summary, our findings indicate that WYD exerts significant therapeutic effects in DSS-induced UC. WYD alleviates intestinal inflammation and injury by reshaping macrophage polarization, attenuating oxidative stress, and modulating the PI3K/AKT/mTOR/HIF-1α signaling pathway. This study provides a potential therapeutic strategy for UC in the future.
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