Cancer vaccines represent a promising approach in cancer immunotherapy aimed at stimulating the immune system to recognize and eliminate tumor cells. Despite early challenges and limited clinical success, recent advances in tumor genomics, antigen discovery, and vaccine technologies have significantly improved their potential. Personalized vaccines, neoantigen targeting, and mRNA-based platforms offer improved specificity and adaptability to tumor heterogeneity. The use of cancer vaccines in combination with other therapies and in early-stage or adjuvant settings further enhances their effectiveness. Although challenges remain, ongoing research suggests that cancer vaccines may play a vital role in future precision cancer treatment strategies.