The expression and clinical significance of p16 protein in cervical cancer and cervical intraepithelial neoplasia

Objective To discuss the expression of p16 protein in cervical cancer,cervical precancerosis and cervical inflammation,explore the biological marker of diagnosis early in cervical cancer and cervical precancerosis.Methods The expression of p16 protein in 23 cases of cervical cancer,63 cases of cervical intraepithelial neoplasia(CIN) and 20 cases cervical inflammation were detected by immunohistochemical staining,and to analyse and compare the results.Results(1)The positive rates of p16 protein in cervical cancer and CINⅠ,CINⅢ and CINⅠ showed significant difference(P0.05);the positive rates of p16 protein in cervical cancer and cervical inflammation,CIN and cervical inflammation showed significant difference too(P0.05);(2)With the development of cervical lesion,the expression intensity and the positive expression of p16 were elevated uncreasingly(P0.001).Conclusion The expression of p16 is related to cervical cancer and the extent and development of CIN lesion,it is suggested that p16 protein expression may be taken as a biomarkers for early diagnosis of cervical cancer and CIN.