2-hydrazino-benzothiazole was synthesized by the benzothiazole and hydrazine hydrate and 6-bromo-2-hydrazino-benzothiazole was synthesized by brom(o)-. 0-[(6 bromo-2-benzothiazole hydrazono) methyl] phenol was also synthesized by 6-bromo-2-hydrazino-benzothiazole and salicylide .the different modified benzothiazole also was synthesized . The effects of mould proofing of different benzothiazole derivate to leather were investigated. The results shows there are good effects that benzothiazole derivate to leather . that the effect of mildewproof was better by brom (o)-and form of Schiff's base .this show there is effective of structure stratum of activity by brom(o)-and form of Schiff's base .