医学
胃窦
幽门螺杆菌
胃肠病学
内科学
胃
胃炎
组织学
肠化生
胃粘膜
活检
胃窦
病理
内窥镜检查
快速尿素酶试验
螺旋藻科
作者
Carlo Calabrese,G. Di Febo,Giovanni Brandi,Antonio Maria Morselli-Labate,A. Areni,C. Scialpi,Guido Biasco,M. Miglioli
出处
期刊:Italian Journal of Gastroenterology and Hepatology
日期:1999-06-01
卷期号:31 (5): 359-365
被引量:35
摘要
Background Helicobacter pylori induces histologic inflammation of mucosa variably correlated to different macroscopic features. Recent studies highlight that the presence of Helicobacter pylori could be assessed on the basis of the macroscopic pattern only, in particular nodularity. The present prospective study has correlated this and other endoscopic features, defined by Sydney classification of gastritis, both to Helicobacter pylori presence and histological patterns. Results Out of 532 patients, 364 were evaluable. The prevalence of Helicobacter pylori was 51.1% with a different distribution between the endoscopic features. Nodularity showed the highest positive predictive value in detecting the Helicobacter pylori presence (69.9%). The histological findings were: normal 26.9%, non atrophic gastritis 55.2%, atrophic gastritis 17.9%. There was a significant difference between abnormal endoscopic features in detecting the histologic gastritis, with endoscopic atrophy and nodularity showing the highest positive predictive value which reaches 96.7% and 91.8%, respectively. Helicobacter pylori infection and histologic gastritis were also present in 30.9% and 41.8%, respectively, of endoscopically normal subjects. Multivariate analysis has strictly correlated age with all abnormal endoscopic features, metaplasia with endoscopic atrophy, and chronic inflammation (gastritis) with nodularity. Conclusions The single endoscopic features are poorly correlated with histologic changes and Helicobacter pylori status. Biopsies are mandatory in all cases. The causes of the different macroscopic findings are not yet fully understood.
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