Study on the polymorphism of Agomelatine

OBJECTIVE To find out the alteration of physicochemical properties on polymorphic crystalline forms of agomelatine.METHODS Characters of agomelatine polymorphs were detected by equilibrium solubility,DSC,IR and PXRD,while the stability was investigated at room temperature.RESULTS Agomelatine crystalline form Ⅰ-Ⅳ were obtained by polymorphous preparation.The four forms showed different DSC and PXRD patterns.CONCLUSION Different crystalline forms of agomelatine have different influences on physicochemical indexes.The stability of the polymorphic agomelatine is ⅡⅠ,Ⅲ and Ⅳ.