EXPRESSIONS OF iNOS AND 5-HT IN ABNORMAL SCAR TISSUE AND THEIR RELATIONSHIP WITH ITCHING AND PAIN

ObjectiveTo study the expressions of inducible nitric oxide synthase(iNOS) and 5-hydroxytryptamine(5-HT) in abnormal scar and normal skin and their relationship with the scar proliferation and itching or pain.MethodsImmunohistochemical method was adopted to detect iNOS and 5-HT in itching or painful scars and non-itching or non-painful scars and normal skin tissues,the results were semi-quantitatively analyzed by image analysis.ResultsCompared with normal skin,iNOS and 5-HT expression in itching or painful scars were significantly higher(F=25.47,44.92;q=4.39,4.43;P0.01),and iNOS in non-itching or non-painful scars was significantly higher(q=3.96,P0.01),5-HT was no difference(q=2.64,P0.05).In the itching or painful scars,5-HT was significantly higher than in non-itching or non-painful scars(q=3.92,P0.01);no difference was noted in iNOS(q=2.71, P0.05).ConclusioniNOS may correlate with the scarring,and higher expression of iNOS may contribute to it.5-HT may correlate with the itching and painful symptoms of abnormal scars,and higher expressions of it may induce the symptoms.