吡喹酮
日本血吸虫
中国
基线(sea)
传输(电信)
人口
兽医学
星团(航天器)
生物
环境卫生
人口学
地理
医学
血吸虫病
免疫学
蠕虫
渔业
计算机科学
程序设计语言
考古
社会学
工程类
电气工程
作者
Darren J. Gray,Gail Williams,Yuesheng Li,Hong-Gen Chen,Robert S. Li,Simon Forsyth,Adrian Barnett,Jiao Guo,Zijian Feng,Donald P. McManus
出处
期刊:American Journal of Tropical Medicine and Hygiene
[American Society of Tropical Medicine and Hygiene]
日期:2007-11-01
卷期号:77 (5): 866-874
被引量:54
标识
DOI:10.4269/ajtmh.2007.77.866
摘要
We describe the design and report baseline results of a cluster-randomized intervention to determine the importance of bovines for Schistosoma japonicum transmission in southern China. The study involves four matched village pairs in Hunan and Jiangxi Provinces, with a village within each pair randomly selected as intervention (human and bovine praziquantel treatment) or control (human praziquantel treatment only). Total study population prevalences at baseline were 12.4% (n = 5,390) and 15.2% (n = 1,573) for humans and bovines, respectively; village prevalences were similar within pairs. Bovine contamination index calculations showed that bovines less than 24 months of age were responsible for 74% of daily bovine environmental contamination with S. japonicum eggs. The village characteristics and baseline results underpin a rigorous study, which has major implications for deployment of a transmission-blocking bovine vaccine against S. japonicum. The combination of such a vaccine with other control strategies could potentially eliminate S. japonicum from southern China.
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