Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management

Abstract Targeting gut flora to lower sickness risk is a growing scientific subject. The intricate network of microorganisms (gut microbiota) in the human intestines regulates many physiological systems and may be important for general health. Recent research has shown a dynamic relationship between gut microbiota and central nervous system (CNS). Dysbiosis is key to establishing and progressing human diseases, including neurodegenerative disorders. Recently, gut microbiota extracellular vesicles (GMEVs) have been suggested as brain‐gut communication carriers. Vesicle components contact immune receptors, initiating neuroinflammatory immune responses and causing neurodegenerative diseases. This study seeks to explain how the gut microbiota and its extracellular vesicles cause or worsen neurodegenerative diseases. We also highlighted recent advances in our understanding of these GMEVs' and cargo's routes, which could be used in drug delivery treatments. This study also examines the current state and potential therapeutic effects of GMEVs on neurodegenerative illnesses.