Therapeutic applications of benzoxaborole compounds: a patent and literature analysis (2019–2024)

INTRODUCTION: Benzoxaborole is a boron-based heterocyclic scaffold with remarkable potential in medicinal chemistry. Its unique chemical structure and compatibility with biological systems have enabled the development of innovative drug candidates. Benzoxaborole derivatives exhibit diverse biological activities, including antibacterial, antifungal, antiparasitic, antiviral, anticancer, and anti-inflammatory effects, making them valuable in addressing various medical challenges. AREAS COVERED: This manuscript reviews the medicinal chemistry literature and patent landscape from 2019 to 2024, focusing on the therapeutic potential of benzoxaborole-based compounds. EXPERT OPINION: Benzoxaboroles are gaining recognition as a versatile and innovative class of therapeutics with strong potential in infectious diseases, oncology, and inflammatory conditions. Their unique boron-containing scaffold enables diverse biological interactions and favorable pharmacokinetic properties. While clinical data are still emerging, early results and robust patent activity suggest significant therapeutic value. Advances in synthetic methods, targeted delivery, and computational design are accelerating their development. With continued focused research and strategic clinical validation, benzoxaboroles are well-positioned to address pressing medical challenges, particularly antimicrobial resistance, and could become an integral part of future treatment paradigms across multiple therapeutic areas.