Therapeutic Effects of Fermented and Dried Corn Silk (Zea mays L.) on Induced Hyperuricemia and Hepatic Cell Injury in Wrister Rats

A rare investigation has been made into the prevailing Hyperuricemia rate in developing countries. In Hyperuricemia (inclined serum uric acid) monosodium urate crystals deposit in joints and tissues. The goal of this research was to access the therapeutic effects of fermented corn silk tea and corn silk powder on hyperuricemia and their action to reduce hepatotoxicity in vivo, 80% ethanol extraction of fermented corn silk alleviated serum uric acid levels in an induced hyperuricemia Wrister rat model by Gentamycin. The efficacy study was for 45 days, containing 30 animals (male and female rats) divided into 6 groups (5 Wister rats in each group) with an average weight of 180 g/kg. G0 and G01 were control groups, groups 1 or 2 were induced and groups 3 and 4 were without induced hyperuricemia. Group 1 (induced hyperuricemia) and Group 3 (without induction) were given the extract of fermented corn silk tea and group 2 and 4 were given the corn silk powder in feed. In the hyperuricemia-induced group, the mean value of uric acid, creatinine, Alanine transaminase, and Aspartate transaminase showed a significant decrease for those who were treated with fermented corn silk tea. Dried corn silk powder showed mixed results of the mean value of uric acid, creatinine, Alanine transaminase, and Aspartate transaminase. Fermented corn silk had the best effect in reducing the raised serum uric acid. The results manifested a remarkable (p<0.05) decrease in serum uric acid, creatinine, Alanine transaminase, and Aspartate transaminase levels. The findings suggest that using fermented corn silk could be an effective strategy to alleviate hyperuricemia in the population predisposed to the development of gout and kidney stones in later stages and can lower the aggregated levels of liver cell injury.