Stereoselective Decarboxylative C -Alkenylation of Anomeric Glycosyl Carboxylic Acids through Cobalt–Photoredox Dual Catalysis

Alkenyl C -glycosides hold significant value across diverse applications, yet their synthetic methodologies remain underdeveloped. Particularly, the simultaneous precise control of the anomeric selectivity and the geometry of the double bond poses a formidable synthetic challenge. Herein, we report that the use of a cost-effective and nontoxic cobaloxime complex enables a dual anomeric and Z/E -stereoselective photocatalytic synthesis of alkenyl C -glycosides from simple and stable glycosyl carboxylic acids and terminal alkenes.