A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating the AKT/mTOR-autophagy pathway

(Molecular Therapy 31; January 2023) In the originally published version of this article, a hyphen was omitted in the title due to a production error. The correct title is “A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating the AKT/mTOR-autophagy pathway.” Cell Press apologizes for this error, and this has been corrected online. A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating the AKT/mTOR-autophagy pathwayOuyang et al.Molecular TherapySeptember 14, 2022In BriefAutophagy regulated by circRNAs is of concern in ischemic acute kidney injury (AKI). Herein, we find that highly expressed circ-ZNF609-encoded ZNF609-250aa induces cell apoptosis and AKI by impairing autophagy flux via the AKT/mTOR signaling pathway. These findings imply that targeting circ-ZNF609 may be a novel therapy for ischemic AKI. Full-Text PDF