部分
叶立德
反应性(心理学)
硫黄
分子
氟
化学
有机合成
计算化学
组合化学
有机化学
医学
替代医学
病理
催化作用
作者
Marcio Hayashi,Antonio C. B. Burtoloso
标识
DOI:10.1002/chem.202400108
摘要
Organic molecules containing fluorine and sulfur atoms represent a large percentage of approved pharmaceuticals. Those with combination of both S and F atoms in their structure such as Xtandi, approved in 2012 for prostate cancer, indicates the importance of synthetic methods that accommodates both atoms in an organic moiety. In this study, a novel aspect of sulfoxonium ylide reactivity was explored, unveiling a streamlined and mild synthesis method for gem‐difluorinated keto‐sulfoxides. Our protocol offers a direct and practical approach to prepare these compounds in 14‐80% chemical yields, that were represented by 21 examples. NMR studies and Hammett correlations gave strong evidence about the mechanism of this transformation.
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