医学
结直肠癌
免疫疗法
肿瘤科
癌症免疫疗法
癌症
内科学
微卫星不稳定性
系列(地层学)
生物
古生物学
等位基因
生物化学
微卫星
基因
作者
María San Román,Íñigo Martínez-Delfrade,Víctor Albarrán-Fernández,Patricia Guerrero-Serrano,Javier Pozas-Pérez,Jesús Chamorro-Pérez,Diana Rosero-Rodríguez,Pilar Sotoca-Rubio,Ana Maria Barrill-Corpa,Víctor Alia-Navarro,Carlos González-Merino,Coral García-de-Quevedo-Suero,Verónica López López,Ignacio Ruz-Caracuel,Cristian Perna-Monroy,Reyes Ferreiro-Monteagudo
标识
DOI:10.3389/fimmu.2024.1352262
摘要
Immunotherapy has demonstrated a role in the therapeutic landscape of a small subset of patients with colorectal carcinoma (CRC) that harbor a microsatellite instability (MSI-H) status due to a deficient DNA mismatch repair (dMMR) system. The remarkable responses to immune checkpoint inhibitors (ICIs) are now being tested in the neoadjuvant setting in localized CRC, where the dMMR/MSI-H status can be found in up to 15% of patients, with remarkable results obtained in NICHE2 and 3 trials, among others. This case series aims to report our experience at a tertiary center and provide a comprehensive analysis of the possible questions and challenges to overcome if ICIs were established as standard of care in a neoadjuvant setting, as well as the potential role they may have as conversion therapy not only in locoregional advanced CRC but also in oligometastatic disease.
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