脱氧胆酸
鹅去氧胆酸
脂肪细胞
化学
脂肪组织
细胞溶解
胆汁酸
内分泌学
内科学
生物化学
医学
细胞毒性T细胞
体外
作者
Weinan Zhou,Benjamin Lew,Hyungsoo Choi,Kyekyoon Kim,Sayeepriyadarshini Anakk
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-01-26
标识
DOI:10.1021/acs.nanolett.3c04352
摘要
Excess fat accumulation is not only associated with metabolic diseases but also negatively impacts physical appearance and emotional well-being. Bile acid, the body’s natural emulsifier, is one of the few FDA-approved noninvasive therapeutic options for double chin (submental fat) reduction. Synthetic sodium deoxycholic acid (NaDCA) causes adipose cell lysis; however, its side effects include inflammation, bruising, and necrosis. Therefore, we investigated if an endogenous bile acid, chenodeoxycholic acid (CDCA), a well-known signaling molecule, can be beneficial without many of the untoward effects. We first generated CDCA-loaded nanoparticles to achieve sustained and localized delivery. Then, we injected them into the subcutaneous fat depot and monitored adipocyte size and mitochondrial function. Unlike NaDCA, CDCA did not cause cytolysis. Instead, we demonstrate that a single injection of CDCA-loaded nanoparticles into the subcutaneous fat reduced the adipocyte size by promoting fat burning and mitochondrial respiration, highlighting their potential for submental fat reduction.
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