嵌合抗原受体
免疫疗法
实体瘤
癌症研究
细胞疗法
肿瘤微环境
细胞
医学
肿瘤细胞
免疫系统
免疫学
癌症
生物
内科学
遗传学
作者
Lu Wang,Xinyi Chen,Lu Zhang,Boning Niu,Long Li,Yinan Sun,Xianglin Yuan
标识
DOI:10.1016/j.intimp.2022.109345
摘要
In addition to chimeric antigen receptor (CAR)-αβ T-cell therapy, CAR-NK, CAR-NKT, CAR-M and CAR-γδ T-cell therapy have gradually been applied to the treatment of solid tumors. Compared to hematological tumors, solid tumors have the characteristics of strong tumor heterogeneity, limited target antigen selection, and low T-cell infiltration to build immunosuppressive tumor microenvironment. These features would present great obstacles to CAR cell therapy. This paper comprehensively analyzed the application of different CAR cells to solid tumors and summarized the design principles of different CAR cells to provide the direction for the development of CAR cell therapy in solid tumors.
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