Synergistic effect of cobalt and cerium on the structural properties and biological behavior of sol-gel-derived mesoporous bioactive glass nanoparticles

Chronic wounds are challenging to treat due to their complex interactions with the skin and underlying tissues. Bioactive glass (BG) has shown promise in treating these wounds, but more research is needed to fully understand its potential. In this study, spherical mesoporous BG nanoparticles were prepared by the sol-gel process, with Ce and Co incorporated into the glass matrix by a post-modification procedure. The release profile of Si, Ce, and Co was monitored over 14 days using simulated exudate fluid (SEF), which has not been previously reported in the literature. The structural properties and biological behavior were evaluated using various techniques, which showed that Ce and Co had a synergistic effect on BG, resulting in samples with high cell viability and antibacterial activity. This study may contribute to the further development of biomaterials for skin wound healing.