炎症体
多巴胺
信号转导
吡喃结构域
多巴胺能
药理学
医学
细胞生物学
兴奋剂
多巴胺受体
炎症
内分泌学
内科学
受体
生物
作者
Chin‐Sheng Chen,Lei Wan,Yueh Ching Chou,Der-Yen Lee,Peng-Tai Tien,Yao-Chien Wang,Ching‐Yao Chang,En‐Shyh Lin,J Chen,Ming-Yen Wu,Hsiangyu Ku,Dekang Gan,Yaotsu Chang,Hui‐Ju Lin,Lei Wan
标识
DOI:10.1177/09645284231170886
摘要
Background: Dopamine has been suggested to be a stop signal for eye growth and affects the development of myopia. Acupuncture is known to increase dopamine secretion and is widely used to treat myopia clinically. Objective: The aim of this study was to determine if acupuncture inhibits myopia progression in form deprived Syrian hamsters by inducing rises in dopamine content that in turn suppress inflammasome activation. Methods: Acupuncture was applied at LI4 and Taiyang every other day for 21 days. The levels of molecules associated with the dopamine signaling pathway, inflammatory signaling pathway and inflammasome activation were determined. A dopamine agonist (apomorphine) was used to evaluate if activation of the dopaminergic signaling pathway suppresses myopia progression by inhibiting inflammasome activation in primary retinal pigment epithelial (RPE) cells. A dopamine receptor 1 (D1R) inhibitor (SCH39166) was also administered to the hamsters. Results: Acupuncture inhibited myopia development by increasing dopamine levels and activating the D1R signaling pathway. Furthermore, we also demonstrated that nucleotide-binding oligomerization domain (NOD)-, leucine-rich repeat (LRR)- and pyrin domain-containing protein 3 (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome activation was inhibited by activation of the D1R signaling pathway. Conclusion: Our findings suggest that acupuncture inhibits myopia development by suppressing inflammation, which is initiated by activation of the dopamine—D1R signaling pathway.
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