生物相容性
壳聚糖
姜黄素
抗菌活性
金黄色葡萄球菌
化学
伤口愈合
体内
纳米颗粒
微生物学
材料科学
核化学
细菌
纳米技术
医学
有机化学
外科
生物化学
生物
生物技术
遗传学
作者
Xiao Han,Weijia Gao,Zhe Zhou,Yongli Li,Daolai Sun,He Gong,Mengyuan Jiang,Ying Gan,Xin Fang,Yuanzheng Qi,Junjie Jiao,Jinghui Zhao
标识
DOI:10.1016/j.ijbiomac.2024.131372
摘要
Clinically, open wounds caused by accidental trauma and surgical lesion resection are easily infected by external bacteria, hindering wound healing. Antibacterial photodynamic therapy has become a promising treatment strategy for wound infection. In this study, a novel antibacterial nanocomposite material (QMC NPs) was synthesized by curcumin, quaternized chitosan and mesoporous polydopamine nanoparticles. The results showed that 150 μg/mL QMC NPs had good biocompatibility and exerted excellent antibacterial activity against Staphylococcus aureus and Escherichia coli after blue laser irradiation (450 nm, 1 W/cm2). In vivo, QMC NPs effectively treated bacterial infection and accelerated the healing of infected wounds in mice.
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