The extracellular vesicle biomolecular corona: current insights and diagnostic potential

characterization techniques currently employed to study the EVs and EV corona complexes, highlighting their respective advantages and limitations. Finally, we discuss how advancing our understanding of the EV corona could significantly improve the robustness of EV-based biomarkers and enhance the specificity of liquid biopsy strategies, ultimately contributing to the development of next-generation precision medicine and personalized diagnostics.