生物
中国
遗传多样性
系统发育树
2019年冠状病毒病(COVID-19)
病毒学
冠状病毒
基因型
拉伤
入射(几何)
腹泻
基因
遗传学
人口学
地理
考古
医学
人口
内科学
疾病
社会学
传染病(医学专业)
物理
解剖
光学
作者
Nuowa Li,Yiming Bai,Runhang Liu,Zhiyuan Guo,Xin Yan,Kongrui Xiang,Feng Liu,Lili Zhao,Junwei Ge
标识
DOI:10.1016/j.cimid.2023.101956
摘要
Canine coronavirus (CCoV) is associated with diarrhea in dogs, with a high incidence and sometimes even death. However, there is currently limited information about its prevalence and molecular characterization in northeastern China. Therefore, in this study, we examined 325 canine fecal specimens in four provinces in northeastern China from 2019 to 2021. PCR results revealed that 57 out of 325 (17.5%) samples were found to be positive for CCoV, and the positive rate varies obviously with city, season, age and so on. High incidence (65%) of viral co-infection was detected in the diarrhea samples and mixed infection of distinct CCoV genotypes occurs extensively. More importantly, sequence analysis showed that the S gene has a strong mutation. Phylogenetic analysis demonstrated that CCoV-I and CCoV-II strains has different origins. In particular, we found the CCoV-IIa strains of S gene sequenced and the reference strain B906_ZJ_2019 were highly clustered, and the reference strain was a recombinant strain of CCoV-I and CCoV-II. Our findings provide useful orienting clues for evaluating the pathogenic potential of CCoV in canines, and point out more details on characterization in northeastern China. Further work is required to determine the significance and continuous genetic evolution of CCoV.
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