Black Phosphorus Nanosheet-Based Composite Biomaterials for the Enhanced Repair of Infectious Bone Defects

Infectious bone defects pose significant challenges in orthopedic practice, marked by persistent bacterial infection and ongoing inflammatory responses. Recent advancements in bone tissue engineering have led to the development of biomaterials with both antibacterial properties and the ability to promote bone regeneration, offering new solutions to these complex issues. Black phosphorus nanosheets (BPNS), a unique two-dimensional material, demonstrate exceptional biocompatibility, bioactivity, and antibacterial properties. Their combination of osteogenic, antibacterial, and anti-inflammatory effects positions BPNS as an ideal candidate for addressing bone defects complicated by infection. This Review explores the potential of BPNS-based composite biomaterials in repairing infectious bone defects, discussing their molecular mechanisms for antibacterial activity, including intrinsic antibacterial properties, photothermal therapy (PTT), photodynamic therapy (PDT), and drug delivery. The application of BPNS in treating infectious bone defects, through hydrogels, scaffolds, coatings, and fibers, is also discussed. The Review emphasizes the transformative role of BPNS in bone tissue engineering and advocates for continued research and development in this promising field.