医学
肺动脉
肺动脉高压
运行x2
心脏病学
钙化
内科学
病理
内分泌学
癌症研究
转录因子
生物
生物化学
基因
作者
Shao‐Fei Liu,Mariya M. Kucherenko,Pengchao Sang,Qiuhua Li,Juquan Yao,N. Nambiar Veetil,Tara Gransar,Ioana Alesutan,Jakob Voelkl,Gabriela Salinas,Jana Grune,Szandor Simmons,Christoph Knosalla,Wolfgang M. Kuebler
出处
期刊：The European respiratory journal
[European Respiratory Society]
日期：2024-11-01
卷期号：64 (5): 2300844-2300844
被引量：15
标识
DOI：10.1183/13993003.00844-2023
摘要
Pulmonary hypertension due to left heart disease is associated with pulmonary artery calcification that is driven by TAZ-dependent stabilisation of RUNX2, causing osteogenic reprogramming of pulmonary artery smooth muscle cells. The TAZ-RUNX2 axis may present a therapeutic target in pulmonary hypertension due to left heart disease.
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(2025-6-4)
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